PREVALÊNCIA DE PAPILOMAVÍRUS HUMANO EM CARCINOMAS EPIDERMÓIDES DE CAVIDADE ORAL E CORRELAÇÃO COM DADOS CLÍNICOS E HISTOPATOLÓGICOS

Abstract

The survival rate of the oral cancer are estimated at about 40% to 50% and is closely related to clinical staging. Tabacco and alcohol consumption are known carcinogenic factors. HPV is strongly associated with oropharyngeal cancer development. Your relation with cancers of the oral cavity has been studied. In this study we analyzed the HPV prevalence in oral cavity tumors and its correlation with clinical and histopathologic data. Methods: 49 cases squamous cell carcinoma of the oral cavity were included in this study. The detection of HPV DNA was made by polymerase chain reaction (PCR) using the primers set MY09 / MY11 and GP6 / GP5. All samples were correlated with clinical and histopathologic data. Results: The HPV prevalence of epidermoid carcinoma of the oral cavity was 54% (25 Patients). There was no significant difference between patients HPV positive and negative in relation to age, sex, smoking and alcohol consumption, staging and lymph node metastasis. 32% (n = 15) of patients were diagnosed in early stage (T1 and T2), and 67.4% (n = 31) were diagnosed in advanced stage (T3-T4). Recurrences were associated with a worse prognosis and were common tumors in HPV negative advanced stage (p=0.04). However, the survival rate was better in patients negative HPV (p=0,026). Conclusion: Clinical factors: recurrence, second primary tumor and distant metastases had a negative impact on overall survival. The correlation of HPV positive tumors with clinical and histopathologic data was statistically significant. as overall survival, which was higher in HPV negative tumors. Among advanced tumor stages (ECIII and stage IV) recurrences were more frequent in HPV-negative tumors.