LINFOGRAFIA INDIRETA E COLORIMÉTRICA: ANÁLISE COMPARATIVA NA DETECÇÃO DE METÁSTASE LINFONODAL EM CADELAS COM TUMOR DE MAMA

Abstract

The precise sentinel lymph node identification (LS) is crucial for câncer patients’ staging and treatment, allowing more effective and less invasive surgical procedure. This study compares indirect X-ray lymphography (LIRx) and colorimetric lympography effectiveness in sentinel node mapping in dogs with breast tumor. 20 dogs with breast tumor and no signs of distant metastasis were included and received both lymphography methods. The LIRx was performed using the water-soluble contrast medium, iomeprol, and the colorimetric lymphography used the patent blue V dye. Lymph nodes identified were removed surgically and histopathological analysis was performed. Both methods were efficient in detecting 65% LS. The consistency between two methods was 30%. Metastases were detected in 30% lymph nodes analyzed.Regional lymph node and LS divergence was observed only by LIRx. Based on our results, LIRx with iomeprol has proved to be a viable and efficient technique to LS identification, mainly to pre-operative visualization and surgical planning, but LICol with patent blue V has proved indispensable for transoperative visualization and assertive surgery exheresis. Methods association has proved clinically relevant; however, more comparative studies are needed to broaden this practice into the veterinary routine.