Corante azul patente como identificador de linfonodo sentinela em cadelas com neoplasia de mama

Abstract

Mammary gland tumours are one of the most common neoplastic disease in both women and intact female dogs. The lymph node status is an important predictor of clinical outcome, and the patients survival decreases drastically when these lymph node are metastatic. However, there are no current and well-defined protocols for the staging and treatment of these metastases in bitches. Thus, the aims of this study are to elucidate the rate of sentinel node detection, as well as the ability to predict inguinal and axillary lymph node metastases in bitches with mammary cancer. Thus, twenty-three female dogs with breast mammary neoplasia and treated at the Veterinary School Clinic (CEVET) of UNICENTRO/Guarapuava-PR were recruited. The protocol included data collection, physical examination, radiological, hematologic and surgery. After anesthetic induction, the intratumoral administration of the patent blue dye was perform. Pass ten minutes was monitored the dye migration and then a mastectomy was carried. Inguinal sentinel lymph nodes were marked in 93.33% of cases and the axillaries in 87.5%. The occurrence of lymph node metastasis was observed in 13.33% of inguinal lymph nodes. Despite the investigation of the inguinal sentinel lymph node does not change the surgical procedure protocol, since it is removed in monobloc at the mastectomy, the lymph node research can improve the lymph node staging on female dogs, without significant morbidity changes.