Comparação da Resposta Imune Estimulada por Vacina Intranasal e Intramuscular Contra Viroses Respiratórias Bovinas

Abstract

The worldwide impact on respiratory volume in cattle (CRB), the world market has been proposed for the control of nurses, investing mainly commercial vaccines. Among the vaccines available on the market, there is still no consensus on the best route of administration, since intranasal vaccines stimulate a higher humoral response, but seem to impact a cellular disease by mimicking a viral infection, whereas intramuscular vaccines interfere less in both immune responses. In this way no work was found on the impact of two vaccination works on the irritation, without cytological profile, without cellular oxidative metabolism and with the production of IgA immunoglobulin of the bronchoalveolar region, in 16 healthy Jersey calves (18±2 months), according to the control groups (CO) (n=5) intranasal (IN) (n=7) and intramuscular (IM) (n=5). The IM group presented nasopharyngeal irritation and a significant reduction of macrophages within 7 days after vaccination and did not alter IgA production. The IN group presented nasopharyngeal irritation, increase of cellularity by neutrophil increase and reduction of macrophages and reduction of the cellular oxidative metabolism of the bronchoalveolar region on days 3 to 21 after vaccination, with a greater magnitude of changes on day 7 and a significant increase of the levels of IgA within three days after vaccination.It is concluded that an intranasal vaccine reduced the cellular immune response but there is a humoral response and intramuscular vacancy can be found for CRB during the establishment of vaccine immunity.